<?xml version="1.0" encoding="us-ascii"?>
<!--Generated by Broadridge PROfile 24.3.1.5224 Broadridge-->
<xs:schema targetNamespace="http://quantum-si.com/20231231" elementFormDefault="qualified" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:qsi="http://quantum-si.com/20231231" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:dei="http://xbrl.sec.gov/dei/2023" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:us-types="http://fasb.org/us-types/2023" xmlns:srt-types="http://fasb.org/srt-types/2023">
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:type="simple" xlink:href="qsi-20231231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="qsi-20231231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="qsi-20231231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="qsi-20231231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:roleType roleURI="http://quantum-si.com/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
        <link:definition>000100 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/ConsolidatedBalanceSheets" id="ConsolidatedBalanceSheets">
        <link:definition>010000 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/ConsolidatedBalanceSheetsParenthetical" id="ConsolidatedBalanceSheetsParenthetical">
        <!--Parent Role: CONSOLIDATED BALANCE SHEETS-->
        <link:definition>010100 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/ConsolidatedStatementsOfOperationsAndComprehensiveLoss" id="ConsolidatedStatementsOfOperationsAndComprehensiveLoss">
        <link:definition>020000 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/ConsolidatedStatementsOfChangesInConvertiblePreferredStockAndStockholdersEquityDeficit" id="ConsolidatedStatementsOfChangesInConvertiblePreferredStockAndStockholdersEquityDeficit">
        <link:definition>030000 - Statement - CONSOLIDATED STATEMENTS OF CHANGES IN CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY (DEFICIT)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/ConsolidatedStatementsOfCashFlows" id="ConsolidatedStatementsOfCashFlows">
        <link:definition>040000 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/OrganizationAndDescriptionOfBusiness" id="OrganizationAndDescriptionOfBusiness">
        <link:definition>060100 - Disclosure - Organization and Description of Business</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPolicies" id="SummaryOfSignificantAccountingPolicies">
        <link:definition>060200 - Disclosure - Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/BusinessCombination" id="BusinessCombination">
        <link:definition>060300 - Disclosure - Business Combination</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/Acquisition" id="Acquisition">
        <link:definition>060400 - Disclosure - Acquisition</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/InvestmentsInMarketableSecurities" id="InvestmentsInMarketableSecurities">
        <link:definition>060500 - Disclosure - Investments in Marketable Securities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/FairValueOfFinancialInstruments" id="FairValueOfFinancialInstruments">
        <link:definition>060600 - Disclosure - Fair Value of Financial Instruments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/InventoryNet" id="InventoryNet">
        <link:definition>060700 - Disclosure - Inventory, Net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/PropertyAndEquipmentNet" id="PropertyAndEquipmentNet">
        <link:definition>060800 - Disclosure - Property and Equipment, Net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/Leases" id="Leases">
        <link:definition>060900 - Disclosure - Leases</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/AccruedExpensesAndOtherCurrentLiabilities" id="AccruedExpensesAndOtherCurrentLiabilities">
        <link:definition>061000 - Disclosure - Accrued Expenses and Other Current Liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/EquityTransactions" id="EquityTransactions">
        <link:definition>061100 - Disclosure - Equity Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/StockbasedCompensation" id="StockbasedCompensation">
        <link:definition>061200 - Disclosure - Stock-based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/NetLossPerShare" id="NetLossPerShare">
        <link:definition>061300 - Disclosure - Net Loss Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/WarrantLiabilities" id="WarrantLiabilities">
        <link:definition>061400 - Disclosure - Warrant Liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/Restructuring" id="Restructuring">
        <link:definition>061500 - Disclosure - Restructuring</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/IncomeTaxes" id="IncomeTaxes">
        <link:definition>061600 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/RelatedPartyTransactions" id="RelatedPartyTransactions">
        <link:definition>061700 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/CommitmentsAndContingencies" id="CommitmentsAndContingencies">
        <link:definition>061800 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/InsiderTradingArrangements" id="InsiderTradingArrangements">
        <link:definition>061900 - Disclosure - Insider Trading Arrangements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesPolicies" id="SummaryOfSignificantAccountingPoliciesPolicies">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>070200 - Disclosure - Summary of Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesTables" id="SummaryOfSignificantAccountingPoliciesTables">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>080200 - Disclosure - Summary of Significant Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/InvestmentsInMarketableSecuritiesTables" id="InvestmentsInMarketableSecuritiesTables">
        <!--Parent Role: Investments in Marketable Securities-->
        <link:definition>080500 - Disclosure - Investments in Marketable Securities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/FairValueOfFinancialInstrumentsTables" id="FairValueOfFinancialInstrumentsTables">
        <!--Parent Role: Fair Value of Financial Instruments-->
        <link:definition>080600 - Disclosure - Fair Value of Financial Instruments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/InventoryNetTables" id="InventoryNetTables">
        <!--Parent Role: Inventory, Net-->
        <link:definition>080700 - Disclosure - Inventory, Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/PropertyAndEquipmentNetTables" id="PropertyAndEquipmentNetTables">
        <!--Parent Role: Property and Equipment, Net-->
        <link:definition>080800 - Disclosure - Property and Equipment, Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/LeasesTables" id="LeasesTables">
        <!--Parent Role: Leases-->
        <link:definition>080900 - Disclosure - Leases (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/AccruedExpensesAndOtherCurrentLiabilitiesTables" id="AccruedExpensesAndOtherCurrentLiabilitiesTables">
        <!--Parent Role: Accrued Expenses and Other Current Liabilities-->
        <link:definition>081000 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/StockbasedCompensationTables" id="StockbasedCompensationTables">
        <!--Parent Role: Stock-based Compensation-->
        <link:definition>081200 - Disclosure - Stock-based Compensation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/NetLossPerShareTables" id="NetLossPerShareTables">
        <!--Parent Role: Net Loss Per Share-->
        <link:definition>081300 - Disclosure - Net Loss Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/RestructuringTables" id="RestructuringTables">
        <!--Parent Role: Restructuring-->
        <link:definition>081500 - Disclosure - Restructuring (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/IncomeTaxesTables" id="IncomeTaxesTables">
        <!--Parent Role: Income Taxes-->
        <link:definition>081600 - Disclosure - Income Taxes (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesAccountsReceivableNetDetails" id="SummaryOfSignificantAccountingPoliciesAccountsReceivableNetDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090200 - Disclosure - Summary of Significant Accounting Policies, Accounts Receivable, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesMarketableSecuritiesDetails" id="SummaryOfSignificantAccountingPoliciesMarketableSecuritiesDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090202 - Disclosure - Summary of Significant Accounting Policies, Marketable Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesPropertyAndEquipmentNetDetails" id="SummaryOfSignificantAccountingPoliciesPropertyAndEquipmentNetDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090206 - Disclosure - Summary of Significant Accounting Policies, Property and Equipment, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesCapitalizedSoftwareDevelopmentCostsDetails" id="SummaryOfSignificantAccountingPoliciesCapitalizedSoftwareDevelopmentCostsDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090208 - Disclosure - Summary of Significant Accounting Policies, Capitalized Software Development Costs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesImpairmentOfLonglivedAssetsDetails" id="SummaryOfSignificantAccountingPoliciesImpairmentOfLonglivedAssetsDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090210 - Disclosure - Summary of Significant Accounting Policies, Impairment of Long-Lived Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesLeasesDetails" id="SummaryOfSignificantAccountingPoliciesLeasesDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090212 - Disclosure - Summary of Significant Accounting Policies, Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesGoodwillDetails" id="SummaryOfSignificantAccountingPoliciesGoodwillDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090214 - Disclosure - Summary of Significant Accounting Policies, Goodwill (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesWarrantLiabilitiesDetails" id="SummaryOfSignificantAccountingPoliciesWarrantLiabilitiesDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090216 - Disclosure - Summary of Significant Accounting Policies, Warrant Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesWarrantyDetails" id="SummaryOfSignificantAccountingPoliciesWarrantyDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090218 - Disclosure - Summary of Significant Accounting Policies, Warranty (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesRevenueRecognitionDetails" id="SummaryOfSignificantAccountingPoliciesRevenueRecognitionDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090220 - Disclosure - Summary of Significant Accounting Policies, Revenue Recognition (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesDeferredRevenueDetails" id="SummaryOfSignificantAccountingPoliciesDeferredRevenueDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090222 - Disclosure - Summary of Significant Accounting Policies, Deferred Revenue (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesDeferredRevenueDetailsDefault" id="SummaryOfSignificantAccountingPoliciesDeferredRevenueDetailsDefault">
        <link:definition>090222 - Disclosure - Summary of Significant Accounting Policies, Deferred Revenue (Details)Default</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesSellingGeneralAndAdministrativeDetails" id="SummaryOfSignificantAccountingPoliciesSellingGeneralAndAdministrativeDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090224 - Disclosure - Summary of Significant Accounting Policies, Selling, General and Administrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesStockbasedCompensationDetails" id="SummaryOfSignificantAccountingPoliciesStockbasedCompensationDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090226 - Disclosure - Summary of Significant Accounting Policies, Stock-Based Compensation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/SummaryOfSignificantAccountingPoliciesIncomeTaxesDetails" id="SummaryOfSignificantAccountingPoliciesIncomeTaxesDetails">
        <!--Parent Role: Summary of Significant Accounting Policies-->
        <link:definition>090228 - Disclosure - Summary of Significant Accounting Policies, Income Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/BusinessCombinationDetails" id="BusinessCombinationDetails">
        <!--Parent Role: Business Combination-->
        <link:definition>090300 - Disclosure - Business Combination (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/AcquisitionDetails" id="AcquisitionDetails">
        <!--Parent Role: Acquisition-->
        <link:definition>090400 - Disclosure - Acquisition (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/InvestmentsInMarketableSecuritiesDetails" id="InvestmentsInMarketableSecuritiesDetails">
        <!--Parent Role: Investments in Marketable Securities-->
        <link:definition>090500 - Disclosure - Investments in Marketable Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/FairValueOfFinancialInstrumentsSignificantAssumptionsDetails" id="FairValueOfFinancialInstrumentsSignificantAssumptionsDetails">
        <!--Parent Role: Fair Value of Financial Instruments-->
        <link:definition>090600 - Disclosure - Fair Value of Financial Instruments, Significant Assumptions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/FairValueOfFinancialInstrumentsAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetails" id="FairValueOfFinancialInstrumentsAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetails">
        <!--Parent Role: Fair Value of Financial Instruments-->
        <link:definition>090602 - Disclosure - Fair Value of Financial Instruments, Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/InventoryNetDetails" id="InventoryNetDetails">
        <!--Parent Role: Inventory, Net-->
        <link:definition>090700 - Disclosure - Inventory, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/PropertyAndEquipmentNetDetails" id="PropertyAndEquipmentNetDetails">
        <!--Parent Role: Property and Equipment, Net-->
        <link:definition>090800 - Disclosure - Property and Equipment, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/LeasesLeaserelatedCostsDetails" id="LeasesLeaserelatedCostsDetails">
        <!--Parent Role: Leases-->
        <link:definition>090902 - Disclosure - Leases, Lease-Related Costs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/LeasesMaturitiesOfOperatingLeaseLiabilitiesDetails" id="LeasesMaturitiesOfOperatingLeaseLiabilitiesDetails">
        <!--Parent Role: Leases-->
        <link:definition>090904 - Disclosure - Leases, Maturities of Operating Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/LeasesSupplementalCashFlowInformationDetails" id="LeasesSupplementalCashFlowInformationDetails">
        <!--Parent Role: Leases-->
        <link:definition>090906 - Disclosure - Leases, Supplemental Cash Flow Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/LeasesFutureMinimumLeasePaymentsUnderNoncancellableLeasesDetailsCalc2" id="LeasesFutureMinimumLeasePaymentsUnderNoncancellableLeasesDetailsCalc2">
        <!--Parent Role: Leases, Maturities of Operating Lease Liabilities (Details)-->
        <link:definition>090906 - Disclosure - LEASES, Future Minimum Lease Payments Under Non-Cancellable Leases (Details) Calc 2</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/LeasesNewHavenConnecticutDetails" id="LeasesNewHavenConnecticutDetails">
        <!--Parent Role: Leases-->
        <link:definition>090908 - Disclosure - Leases, New Haven, Connecticut (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/AccruedExpensesAndOtherCurrentLiabilitiesDetails" id="AccruedExpensesAndOtherCurrentLiabilitiesDetails">
        <!--Parent Role: Accrued Expenses and Other Current Liabilities-->
        <link:definition>091000 - Disclosure - Accrued Expenses and Other Current Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/EquityTransactionsDetails" id="EquityTransactionsDetails">
        <!--Parent Role: Equity Transactions-->
        <link:definition>091100 - Disclosure - Equity Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/StockbasedCompensationEquityIncentivePlanAndInducementEquityIncentivesDetails" id="StockbasedCompensationEquityIncentivePlanAndInducementEquityIncentivesDetails">
        <!--Parent Role: Stock-based Compensation-->
        <link:definition>091200 - Disclosure - Stock-based Compensation, Equity Incentive Plan and Inducement Equity Incentives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/StockbasedCompensationStockOptionActivityDetails" id="StockbasedCompensationStockOptionActivityDetails">
        <!--Parent Role: Stock-based Compensation-->
        <link:definition>091202 - Disclosure - Stock-based Compensation, Stock Option Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/StockbasedCompensationAssumptionsUsedToValueOptionGrantsDetails" id="StockbasedCompensationAssumptionsUsedToValueOptionGrantsDetails">
        <!--Parent Role: Stock-based Compensation-->
        <link:definition>091204 - Disclosure - Stock-based Compensation, Assumptions Used to Value Option Grants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/StockbasedCompensationRsuActivityDetails" id="StockbasedCompensationRsuActivityDetails">
        <!--Parent Role: Stock-based Compensation-->
        <link:definition>091206 - Disclosure - Stock-based Compensation, RSU Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/StockbasedCompensationStockbasedCompensationExpenseDetails" id="StockbasedCompensationStockbasedCompensationExpenseDetails">
        <!--Parent Role: Stock-based Compensation-->
        <link:definition>091208 - Disclosure - Stock-based Compensation, Stock-Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/NetLossPerShareDetails" id="NetLossPerShareDetails">
        <!--Parent Role: Net Loss Per Share-->
        <link:definition>091300 - Disclosure - Net Loss Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/WarrantLiabilitiesDetails" id="WarrantLiabilitiesDetails">
        <!--Parent Role: Warrant Liabilities-->
        <link:definition>091400 - Disclosure - Warrant Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/RestructuringDetails" id="RestructuringDetails">
        <!--Parent Role: Restructuring-->
        <link:definition>091500 - Disclosure - Restructuring (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/IncomeTaxesComponentsOfLossBeforeProvisionForIncomeTaxesDetails" id="IncomeTaxesComponentsOfLossBeforeProvisionForIncomeTaxesDetails">
        <!--Parent Role: Income Taxes-->
        <link:definition>091600 - Disclosure - Income Taxes, Components of Loss before Provision for Income Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/IncomeTaxesStatutoryToEffectiveIncomeTaxRateReconciliationDetails" id="IncomeTaxesStatutoryToEffectiveIncomeTaxRateReconciliationDetails">
        <!--Parent Role: Income Taxes-->
        <link:definition>091602 - Disclosure - Income Taxes, Statutory to Effective Income Tax Rate Reconciliation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/IncomeTaxesProvisionForIncomeTaxesDetails" id="IncomeTaxesProvisionForIncomeTaxesDetails">
        <!--Parent Role: Income Taxes-->
        <link:definition>091604 - Disclosure - Income Taxes, Provision for Income Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/IncomeTaxesDeferredTaxAssetsAndLiabilitiesDetails" id="IncomeTaxesDeferredTaxAssetsAndLiabilitiesDetails">
        <!--Parent Role: Income Taxes-->
        <link:definition>091606 - Disclosure - Income Taxes, Deferred Tax Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/IncomeTaxesNetOperatingLossCarryforwardsDetails" id="IncomeTaxesNetOperatingLossCarryforwardsDetails">
        <!--Parent Role: Income Taxes-->
        <link:definition>091608 - Disclosure - Income Taxes, Net Operating Loss Carryforwards (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/IncomeTaxesTaxCreditCarryforwardsDetails" id="IncomeTaxesTaxCreditCarryforwardsDetails">
        <!--Parent Role: Income Taxes-->
        <link:definition>091610 - Disclosure - Income Taxes, Tax Credit Carryforwards (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/IncomeTaxesUnrecognizedTaxBenefitsDetails" id="IncomeTaxesUnrecognizedTaxBenefitsDetails">
        <!--Parent Role: Income Taxes-->
        <link:definition>091612 - Disclosure - Income Taxes, Unrecognized Tax Benefits (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/RelatedPartyTransactionsDetails" id="RelatedPartyTransactionsDetails">
        <!--Parent Role: Related Party Transactions-->
        <link:definition>091700 - Disclosure - Related Party Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://quantum-si.com/role/CommitmentsAndContingenciesDetails" id="CommitmentsAndContingenciesDetails">
        <!--Parent Role: Commitments and Contingencies-->
        <link:definition>091800 - Disclosure - Commitments and Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:import namespace="http://fasb.org/us-gaap/2023" schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/dei/2023" schemaLocation="https://xbrl.sec.gov/dei/2023/dei-2023.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/country/2023" schemaLocation="https://xbrl.sec.gov/country/2023/country-2023.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/currency/2023" schemaLocation="https://xbrl.sec.gov/currency/2023/currency-2023.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/exch/2023" schemaLocation="https://xbrl.sec.gov/exch/2023/exch-2023.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/naics/2023" schemaLocation="https://xbrl.sec.gov/naics/2023/naics-2023.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/sic/2023" schemaLocation="https://xbrl.sec.gov/sic/2023/sic-2023.xsd" />
  <xs:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xs:import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/stpr/2023" schemaLocation="https://xbrl.sec.gov/stpr/2023/stpr-2023.xsd" />
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xs:import namespace="http://www.xbrl.org/2004/ref" schemaLocation="http://www.xbrl.org/2004/ref-2004-08-10.xsd" />
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xs:import namespace="http://fasb.org/us-types/2023" schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-types-2023.xsd" />
  <xs:import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />
  <xs:import namespace="http://fasb.org/srt/2023" schemaLocation="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd" />
  <xs:import namespace="http://fasb.org/srt-types/2023" schemaLocation="https://xbrl.fasb.org/srt/2023/elts/srt-types-2023.xsd" />
  <xs:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/ecd/2023" schemaLocation="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd" />
  <xs:element name="RedeemableWarrantsEachWholeWarrantExercisableForOneShareOfClassACommonStockEachAtAnExercisePriceOf1150PerShareMember" id="qsi_RedeemableWarrantsEachWholeWarrantExercisableForOneShareOfClassACommonStockEachAtAnExercisePriceOf1150PerShareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="IncreaseDecreaseInOtherAssetsRelatedParties" id="qsi_IncreaseDecreaseInOtherAssetsRelatedParties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="NetProceedsFromEquityInfusionFromBusinessCombination" id="qsi_NetProceedsFromEquityInfusionFromBusinessCombination" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="NoncashOrPartNoncashAcquisitionForgivenessOfRelatedPartyPromissoryNotes" id="qsi_NoncashOrPartNoncashAcquisitionForgivenessOfRelatedPartyPromissoryNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="NoncashOrPartNoncashAcquisitionEquityRelatedTransactionCostsFromBusinessCombination" id="qsi_NoncashOrPartNoncashAcquisitionEquityRelatedTransactionCostsFromBusinessCombination" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="NoncashOrPartNoncashAcquisitionEquityRelatedWarrantsFromBusinessCombination" id="qsi_NoncashOrPartNoncashAcquisitionEquityRelatedWarrantsFromBusinessCombination" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="IncreaseDecreaseInOperatingLeaseRightOfUseAssets" id="qsi_IncreaseDecreaseInOperatingLeaseRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="CashReceivedFromExchangeOfResearchAndDevelopmentTaxCredits" id="qsi_CashReceivedFromExchangeOfResearchAndDevelopmentTaxCredits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="PaymentForDeferredConsideration" id="qsi_PaymentForDeferredConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="BusinessCombinationChangeInFairValueOfStockConsideration" id="qsi_BusinessCombinationChangeInFairValueOfStockConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="PaymentsOfDeferredOfferingCosts" id="qsi_PaymentsOfDeferredOfferingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="DeferredOfferingCostsPayable" id="qsi_DeferredOfferingCostsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="NoncashOrPartNoncashAcquisitionNoncashContingentConsiderationAndHoldbacks" id="qsi_NoncashOrPartNoncashAcquisitionNoncashContingentConsiderationAndHoldbacks" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="AccruedContractedServicesCurrent" id="qsi_AccruedContractedServicesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="StandardProductWarrantyWarrantyPeriod" id="qsi_StandardProductWarrantyWarrantyPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="OperatingLossCarryforwardsNotSubjectToExpirationButSubjectTo80TaxableIncomeLimitation" id="qsi_OperatingLossCarryforwardsNotSubjectToExpirationButSubjectTo80TaxableIncomeLimitation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="OperatingLossCarryforwardsNotSubjectToExpiration" id="qsi_OperatingLossCarryforwardsNotSubjectToExpiration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="Pre2018Member" id="qsi_Pre2018Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="PropertyAndEquipmentDisposalsMember" id="qsi_PropertyAndEquipmentDisposalsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="RestrictedStockExpenseCredit" id="qsi_RestrictedStockExpenseCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="NumberOfMembersOfBoardOfDirectorsReceivingGrantOfRestrictedStockUnit" id="qsi_NumberOfMembersOfBoardOfDirectorsReceivingGrantOfRestrictedStockUnit" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="RestrictedStockUnitsSubjectToServiceMarketAndPerformanceConditionsMember" id="qsi_RestrictedStockUnitsSubjectToServiceMarketAndPerformanceConditionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="RestrictedStockUnitsSubjectToServiceAndOrPerformanceConditionMember" id="qsi_RestrictedStockUnitsSubjectToServiceAndOrPerformanceConditionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="RestrictedStockUnitsSubjectToServiceAndPerformanceConditionsMember" id="qsi_RestrictedStockUnitsSubjectToServiceAndPerformanceConditionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="BoardOfDirectorsChairmanAndDirectorsMember" id="qsi_BoardOfDirectorsChairmanAndDirectorsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="GeneralCounselMember" id="qsi_GeneralCounselMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="EmployeesAndNonemployeesAbstract" id="qsi_EmployeesAndNonemployeesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="StockIssuedDuringPeriodValueBusinessCombination" id="qsi_StockIssuedDuringPeriodValueBusinessCombination" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="StockIssuedDuringPeriodSharesBusinessCombination" id="qsi_StockIssuedDuringPeriodSharesBusinessCombination" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="TemporaryEquityStockIssuedDuringPeriodIssuanceCosts" id="qsi_TemporaryEquityStockIssuedDuringPeriodIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="TemporaryEquityStockConvertedSharesIssued" id="qsi_TemporaryEquityStockConvertedSharesIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="TemporaryEquityStockConvertedSharesIssuedValue" id="qsi_TemporaryEquityStockConvertedSharesIssuedValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" />
  <xs:element name="TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" id="qsi_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="AccruedAcquisitionRelatedFeesCurrent" id="qsi_AccruedAcquisitionRelatedFeesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="NumberOfWarrantsIssuedPerUnitIssued" id="qsi_NumberOfWarrantsIssuedPerUnitIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="DeferredTaxAssetsLeasingArrangements" id="qsi_DeferredTaxAssetsLeasingArrangements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="DeferredTaxAssetsCapitalizedResearchAndDevelopmentExpenses" id="qsi_DeferredTaxAssetsCapitalizedResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="DeferredTaxAssetsUnrealizedGainLossOnDebtSecuritiesTrading" id="qsi_DeferredTaxAssetsUnrealizedGainLossOnDebtSecuritiesTrading" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="QuantumSiIncorporated2021EquityIncentivePlanMember" id="qsi_QuantumSiIncorporated2021EquityIncentivePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="InducementEquityIncentivePlan2023Member" id="qsi_InducementEquityIncentivePlan2023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="AwardedNovember92022Member" id="qsi_AwardedNovember92022Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="PropertyPlantAndEquipmentEstimatedUsefulLivesTableTextBlock" id="qsi_PropertyPlantAndEquipmentEstimatedUsefulLivesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="AtTheMarketEquityOfferingProgramAbstract" id="qsi_AtTheMarketEquityOfferingProgramAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="PercentageOfGrossProceedsFromSaleOfStock" id="qsi_PercentageOfGrossProceedsFromSaleOfStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="CommonStockThatCanBeSold" id="qsi_CommonStockThatCanBeSold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="CommonStockNumberOfVotesPerShare" id="qsi_CommonStockNumberOfVotesPerShare" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="RedeemableWarrantsMember" id="qsi_RedeemableWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="TradingDayPeriodToCalculateFairMarketValueOverExercisePriceOfWarrants" id="qsi_TradingDayPeriodToCalculateFairMarketValueOverExercisePriceOfWarrants" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ClassOfWarrantOrRightRedemptionPrice" id="qsi_ClassOfWarrantOrRightRedemptionPrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="BeneficialOwnershipPercentage" id="qsi_BeneficialOwnershipPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ClassOfWarrantOrRightExercised" id="qsi_ClassOfWarrantOrRightExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="PeriodPriorToNoticeOfRedemption" id="qsi_PeriodPriorToNoticeOfRedemption" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ThresholdConsecutiveTradingDays" id="qsi_ThresholdConsecutiveTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="NoticePeriodToRedeemWarrants" id="qsi_NoticePeriodToRedeemWarrants" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ThresholdTradingDays" id="qsi_ThresholdTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ClassOfWarrantOrRightRedeemed" id="qsi_ClassOfWarrantOrRightRedeemed" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="PrivatePlacementWarrantsMember" id="qsi_PrivatePlacementWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ClassOfWarrantOrRightLimitationPeriodToTransferAssignOrSellWarrants" id="qsi_ClassOfWarrantOrRightLimitationPeriodToTransferAssignOrSellWarrants" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="BusinessCombinationDisclosureTable" id="qsi_BusinessCombinationDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="HighCapeCapitalAcquisitionCorpMember" id="qsi_HighCapeCapitalAcquisitionCorpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="BusinessCombinationDisclosureLineItems" id="qsi_BusinessCombinationDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="CommonStockVotesPerShare" id="qsi_CommonStockVotesPerShare" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="BusinessCombinationExchangeRatio" id="qsi_BusinessCombinationExchangeRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="CommonStockPercentageOfTotalSharesThatMustBeBeneficiallyOwnedIncludedInSunsetProvision" id="qsi_CommonStockPercentageOfTotalSharesThatMustBeBeneficiallyOwnedIncludedInSunsetProvision" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="PipeInvestorsMember" id="qsi_PipeInvestorsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="CertainAffiliatesOfForesiteCapitalManagementLlcMember" id="qsi_CertainAffiliatesOfForesiteCapitalManagementLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="GainLossOnSecuritiesAndInvestmentIncomeTableTextBlock" id="qsi_GainLossOnSecuritiesAndInvestmentIncomeTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="LicensesRelatedToCertainIntellectualPropertyMember" id="qsi_LicensesRelatedToCertainIntellectualPropertyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="OtherCommitmentAnnualMinimumFixedPayments" id="qsi_OtherCommitmentAnnualMinimumFixedPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="MajelacTechnologiesLlcMember" id="qsi_MajelacTechnologiesLlcMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="BusinessCombinationAdditionalSharesToBeIssuedValue" id="qsi_BusinessCombinationAdditionalSharesToBeIssuedValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="BusinessCombinationContingentConsiderationNumberOfMilestonesMet" id="qsi_BusinessCombinationContingentConsiderationNumberOfMilestonesMet" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="BusinessCombinationPeriodToHoldCashBack" id="qsi_BusinessCombinationPeriodToHoldCashBack" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="BusinessCombinationContingentConsiderationNumberOfMilestonesToBeMet" id="qsi_BusinessCombinationContingentConsiderationNumberOfMilestonesToBeMet" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="BusinessCombinationContingentConsiderationLiabilityFairValueDisclosure" id="qsi_BusinessCombinationContingentConsiderationLiabilityFairValueDisclosure" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="BusinessCombinationPeriodToIssueAdditionalSharesAfterClosingDate" id="qsi_BusinessCombinationPeriodToIssueAdditionalSharesAfterClosingDate" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="BusinessCombinationContingentConsiderationMilestoneOneLiabilityFairValueDisclosure" id="qsi_BusinessCombinationContingentConsiderationMilestoneOneLiabilityFairValueDisclosure" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="BusinessCombinationAdditionalSharesToBeIssuedShares" id="qsi_BusinessCombinationAdditionalSharesToBeIssuedShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" />
  <xs:element name="BusinessCombinationCashHeldBack" id="qsi_BusinessCombinationCashHeldBack" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" />
  <xs:element name="EquityIncentivePlans2013And2021Member" id="qsi_EquityIncentivePlans2013And2021Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="StockOptionsSubjectToPerformanceConditionRelatedToBusinessCombinationMember" id="qsi_StockOptionsSubjectToPerformanceConditionRelatedToBusinessCombinationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="StockOptionsSubjectToPerformanceConditionRelatedToCompletionOfFinancingEventMember" id="qsi_StockOptionsSubjectToPerformanceConditionRelatedToCompletionOfFinancingEventMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="FacilityInNewHavenConnecticutMember" id="qsi_FacilityInNewHavenConnecticutMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="LeaseIncentives" id="qsi_LeaseIncentives" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" />
  <xs:element name="Catalyzer4CorporationMember" id="qsi_Catalyzer4CorporationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="OtherCompaniesControlledByRothbergFamilyMember" id="qsi_OtherCompaniesControlledByRothbergFamilyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="BindersCollaborationMember" id="qsi_BindersCollaborationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="MonthlyServicesUnderAmendedAndRestatedTechnologyServicesAgreementMember" id="qsi_MonthlyServicesUnderAmendedAndRestatedTechnologyServicesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="MonthToMonthSubleaseArrangementsForOfficeAndLaboratorySpacesMember" id="qsi_MonthToMonthSubleaseArrangementsForOfficeAndLaboratorySpacesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ProteinEngineeringCollaborationMember" id="qsi_ProteinEngineeringCollaborationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="TransactionsWithRelatedPartiesAbstract" id="qsi_TransactionsWithRelatedPartiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesThatCanBePurchasedWithOptionGranted" id="qsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesThatCanBePurchasedWithOptionGranted" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ExecutiveChairmanAgreementMember" id="qsi_ExecutiveChairmanAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ProteinEvolutionIncMember" id="qsi_ProteinEvolutionIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="ServicesProvidedToParticipantCompaniesUnderAmendedAndRestatedTechnologyServicesAgreementMember" id="qsi_ServicesProvidedToParticipantCompaniesUnderAmendedAndRestatedTechnologyServicesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="EffectiveIncomeTaxRateReconciliationTaxCreditResearchExchangedForCashAmount" id="qsi_EffectiveIncomeTaxRateReconciliationTaxCreditResearchExchangedForCashAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="IncomeTaxDisclosureTable" id="qsi_IncomeTaxDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="IncomeTaxDisclosureLineItems" id="qsi_IncomeTaxDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="RestructuringReservePaymentsForRestructuringAndOtherAdjustments" id="qsi_RestructuringReservePaymentsForRestructuringAndOtherAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" />
  <xs:element name="ShippingAndHandlingCostsPolicyTextBlock" id="qsi_ShippingAndHandlingCostsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="PrepaidExpensesAndOtherCurrentAssetsPolicyPolicyTextBlock" id="qsi_PrepaidExpensesAndOtherCurrentAssetsPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="DeferredRevenuePolicyPolicyTextBlock" id="qsi_DeferredRevenuePolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ConvertiblePreferredStockPolicyTextBlock" id="qsi_ConvertiblePreferredStockPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="SpaceLocatedInNewHavenConnecticutMember" id="qsi_SpaceLocatedInNewHavenConnecticutMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
  <xs:element name="SupplementalCashFlowInformationRelatedToOperatingLeasesTableTextBlock" id="qsi_SupplementalCashFlowInformationRelatedToOperatingLeasesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" abstract="false" xbrli:periodType="duration" />
  <xs:element name="ConnecticutDepartmentOfRevenueServicesMember" id="qsi_ConnecticutDepartmentOfRevenueServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" abstract="true" xbrli:periodType="duration" />
</xs:schema>
